A predictable, dose-related adverse drug reaction is classified as which type of ADR?

A predictable, dose-related adverse drug reaction is classified as which type of ADR?

• A. Type A
• B. Type B
• C. Type C
• D. Type D

Answer: (A)

Adverse drug reactions that are predictable and related to the drug’s pharmacologic action are Type A, the augmented reactions. They arise because the effect is an extension of what the drug does to the body, so as the dose increases, the effect and its side effects tend to increase too. They’re common at therapeutic doses and often reversible by reducing the dose or stopping the drug. Examples include hypoglycemia with insulin, bleeding with anticoagulants, or gastric irritation with NSAIDs. This contrasts with Type B (unpredictable, not dose-related), Type C (chronic effects from cumulative exposure), and Type D (delayed effects).

Adverse drug reactions that are predictable and related to the drug’s pharmacologic action are Type A, the augmented reactions. They arise because the effect is an extension of what the drug does to the body, so as the dose increases, the effect and its side effects tend to increase too. They’re common at therapeutic doses and often reversible by reducing the dose or stopping the drug. Examples include hypoglycemia with insulin, bleeding with anticoagulants, or gastric irritation with NSAIDs. This contrasts with Type B (unpredictable, not dose-related), Type C (chronic effects from cumulative exposure), and Type D (delayed effects).